منابع مشابه
Atherosclerosis regression, vascular remodeling, and plaque stabilization.
hat atherosclerosis regression may be a realistic goal in ome patients. Although the actual amount of plaque egression and compositional change is small, there may be ubstantial clinical benefit. Yet, the question arises: what is he therapeutic mechanism? Is it the reduced dimension of he plaque, the decreased atheroma burden, or the conseuent compositional changes that confer the clinical imro...
متن کاملPathophysiology of atherosclerosis plaque progression.
Atherosclerotic plaque rupture with luminal thrombosis is the most common mechanism responsible for the majority of acute coronary syndromes and sudden coronary death. The precursor lesion of plaque rupture is thought to be a thin cap fibroatheroma (TCFA) or "vulnerable plaque". TCFA is characterised by a necrotic core with an overlying thin fibrous cap (≤65 μm) that is infiltrated by macrophag...
متن کاملImaging atherosclerosis and vulnerable plaque.
Identifying patients at high risk for an acute cardiovascular event such as myocardial infarction or stroke and assessing the total atherosclerotic burden are clinically important. Currently available imaging modalities can delineate vascular wall anatomy and, with novel probes, target biologic processes important in plaque evolution and plaque stability. Expansion of the vessel wall involving ...
متن کاملRegression of Atherosclerosis: The Journey From the Liver to the Plaque and Back.
Cardinal events in atherogenesis are the retention of apolipoprotein B-containing lipoproteins in the arterial wall and the reaction of macrophages to these particles. My laboratory has been interested in both the cell biological events producing apolipoprotein B-containing lipoproteins, as well as in the reversal of the damage they cause in the plaques formed in the arterial wall. In the 2013 ...
متن کاملmiR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.
RATIONALE Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negative regulator of the reverse cholesterol transport factors, ATP-binding casse...
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ژورنال
عنوان ژورنال: Medicinski pregled
سال: 2006
ISSN: 0025-8105,1820-7383
DOI: 10.2298/mpns0602038b